✔ Antioxidant Protection
✔ Healthy Pregnancy and Fertility
✔ Promotes Healthy Skin
✔ Supports Arterial Health and Healthy Cholesterol Levels
✔ Promotes a Healthy Mind and Memory
✔ Promotes Breast Health (Particularly From the Gamma Vitamin E)
Vitamin E, in its natural form, comprises eight different compounds: alpha-, beta-, gamma-, and delta-tocopherols and alpha-, beta-, gamma-, and delta-tocotrienols. Both tocopherols and tocotrienols are important to human health. Known as the “master antioxidant,” vitamin E has the ability to attenuate oxidative stress, and its antioxidant-related effects on various organs and systems have been the focus of vast research. More recently, non-antioxidant mechanisms have been proposed, such as those that affect cellsignal transduction and gene expression. Though the vast majority of research has been on alpha-tocopherol, recent mechanistic studies indicate that other isomers of vitamin E, such as gamma- and deltatocopherols and tocotrienols, have superior antioxidant and cellsignaling properties that offer greater health benefits.
Tocotrienols: Studies have demonstrated that tocotrienols have superior antioxidant activity compared to tocopherols. Tocotrienols also exhibit biological activities related to neuroprotection, radioprotection, cell-life regulation, cytokine modulation, and lipid metabolism that are not shared by tocopherols. Many of these benefits are thought to be mediated via their carboxychromanol metabolites. Among other actions, tocotrienols have been shown to inhibit HMG-CoA reductase (3-hydroxy-3-methylglutaryl-coenzyme A reductase), attenuate transcription factor NF-κB activation, and inhibit COX-2. Given these mechanisms, in addition to their antioxidant mechanisms, tocotrienols have a very broad range of applications. Due to the poor absorption and low bio-availability of tocotrienols, scientists developed EVNol SupraBio™.
EVNol SupraBio: Bio-enhanced tocotrienol/tocopherol complex EVNol SupraBio is a natural, full-spectrum tocopherol and tocotrienol complex extracted and concentrated from the red palm fruits (Elaeis guineensis) of sustainable plantations in Peninsular Malaysia. This vitamin E complex also contains minute amounts of other phytonutrients such as plant squalene, phytosterols, coenzyme Q10, and mixed carotenoids that are naturally extracted together with tocotrienols. This patented formula contains a precise mixture of oil and approved food emulsifiers at optimum ratio and processing that self-emulsifies in the gastrointestinal tract to facilitate and provide a rapid and consistent absorption of tocotrienols into the plasma, independent of dietary fat or food intake.
EVNol SupraBio Human Absorption Studies: Kholsa et al were the first to establish that oral supplementation of EVNol SupraBio resulted in a peak plasma level 12- to 13-fold the level established for neuroprotection. Later, in a two-period, twosequence, crossover study performed in healthy human volunteers, researchers demonstrated that the SupraBio system increased the rate and extent of absorption of individual tocotrienols by an average of 250% compared to a regular tocotrienol oil extract. Moreover, EVNol Suprabio is the only tocotrienol/tocopherol complex in the market that has been the subject of an actual human tissue distribution study. In that study, Patel et al demonstrated that orally supplemented tocotrienols from EVNol SupraBio are absorbed into plasma and delivered and accumulated in vital organs, including the brain.
EVNol SupraBio Human Clinical Studies: EVNol SupraBio is a heavily researched tocopherol/tocotrienol product that has been scientifically substantiated with human clinical studies on brain health, liver support, beauty, and cardiovascular health. For example, in a randomized, placebo-controlled, two-year neuroprotection study (n = 121), supplementation with 200 mg/d EVNol SupraBio attenuated the progression of injury to brain white matter. Three other studies demonstrated the positive effects of EVNol SupraBio on parameters of liver health, and studies related to cardiovascular health suggested that 50-200 mg/d EVNol SupraBio supports healthy lipid (cholesterol, low-density lipoprotein, triglyceride) metabolism and showed a trend toward improved arterial compliance (the ability to expand and contract). Supplementation has also been shown to support the desired immune response to vaccine. And in a randomized, double-blind, placebo-controlled trial (n = 38), volunteers with hair loss who were given 100 mg of EVNol SupraBio daily experienced a 34.5% increase in number of hairs at the end of eight months, compared to a 0.1% increase in the placebo group. The higher activity of tocotrienols in certain organs may, in part, be explained by the fact that the unsaturated side-chain of tocotrienols allow more efficient penetration into tissues, such as brain and liver tissues, that have saturated fatty layers. It is clear from the emerging data that tocopherols and tocotrienols have complementary, unique, and important functions. Providing a formula that supplies the full spectrum of natural vitamin E isomers is an important option for practitioners and their patients.
Per softgel: Vitamin E (d-alpha tocopherol) 33.5mg AT (50 IU); EVNol SupraBio™ Bio-Enhanced Natural Full Spectrum Tocotrienols 25mg (Provides: d-Gamma Tocotrienol 11.5mg, d-Alpha Tocotrienol 7.4mg, d-Delta Tocotrienol 4.1mg, d-Beta Tocotrienol 0.8mg); Mixed tocopherols concentrate 125mg (Provides: d-Gamma Tocopherol 75mg, d-Delta Tocopherol 30mg, d-Beta Tocopherol 2.5mg)
Non-Medicinal Ingredients: Sunflower oil, softgel (bovine gelatin, vegetable glycerin, and purified water), polyglycerol esters of fatty acids.
Recommended Dose: Adults: Take one softgel daily or as directed by your healthcare practitioner.
Contraindications: Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding or have cancer.